POS1253 TIMP-1 AS WELL AS IL-6 IN PULMONARY CAPILLARIES REFLECT THE COMPLICATIONS AND SEVERITY OF PH IN SYSTEMIC SCLERODERMA

Background Abnormal production of various cytokines is involved in the pathogenesis CTD, and cytokine abnormalities vary according to type organ lesion. Recent reports indicate that are also iPAH.1) The differences between PH associated with CTD other PH-associated cytokines, including iPAH, not well defined. relationship severity each clear. Objectives purpose this study was determine profile pulmonary capillaries CTD-PH hemodynamic indicators PH, confirm profiles iPAH. Methods Patients who underwent RHC for diagnosis at our hospital from 2015 2021 years were included study. Serum collected before after during right left heart catheterization performed analysis measured. TIMP-1, IL-21 MCP-1, IL-17, IL-12p70 IL-6, which have been previously reported be measurements measured by ELISA (ABCAM UK). IL-6 (Ella simple plex USA). parameters compared. Statistical analyses using Spearman’s rank correlation coefficient Wilcoxon signed-rank test JMP software v16.1.0 (SAS, Results Eighty-one studies on 56 patients catheterization. Forty-seven female nine male, a mean age 64.2 years. 33 patients, 19 SSc, 10 MCTD, 2 SLE, SS, 23 non-CTD 5 All able diagnose while 11 (8 3 MCTD) unable PH. duration 7.5 group 10.8 nonPH group. Three CTDs could diagnosed vasodilators treatment DU.Ten cases receiving immunosuppressive therapy. WHOFC found no difference non CTD-PH. Mean mPAP 29 +/- 9.3 mmHg 32 non-CTD-PH, significant difference. In an all hypertension, IL-12 levels capillary significantly (p < 0.05). Furthermore, association CTD-PH, SSc-PH, non-CTD-PH (p<0.05). focused TIMP-1 markedly higher SSc (TIMP-1; 134+/-42.8 vs 243+/-135, p <0.05, IL-6; 2.04+/-0.82 21.2+/-80, <0.05).In groups examined time, IL-21, MCP-1 or any parameter. Conclusion capillaries, hemodynamics but only systemic scleroderma. Reference [1]Hashimoto-Kataoka T. et al. Proc Natl Acad Sci U S A. May 19;112(20):E2677-86. Acknowledgements: NIL. Disclosure Interests None Declared.